![]() Zygotic expression of the caudal homolog pal-1 is required for posterior patterning in Caenorhabditis elegans embryogenesis. Ascidian tail formation requires caudal function. Isolation of caudal, a Drosophila homeo box-containing gene with maternal expression whose transcripts form a concentration gradient at the pre-blastoderm stage. Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish Danio rerio. Deciphering the Hox code: clues to patterning branchial regions of the head. Genes controlling segmental specification in Drosophila thorax. A gene complex controlling segmentation in Drosophila. Taken together, these findings demonstrate that cdx4 regulates hox genes and is necessary for the specification of haematopoietic cell fate during vertebrate embryogenesis. Overexpression of cdx4 during zebrafish development or in mouse embryonic stem cells induces blood formation and alters hox gene expression. Furthermore, the haematopoietic defect in kgg mutants is not rescued by scl overexpression, suggesting that cdx4 and hox genes act to make the posterior mesoderm competent for blood development. The blood deficiency in kgg embryos can be rescued by overexpressing hoxb7a or hoxa9a but not hoxb8a, indicating that the haematopoietic defect results from perturbations in specific hox genes. Here, we have identified the caudal-related gene cdx4 as the locus mutated in kugelig ( kgg), a zebrafish mutant with an early defect in haematopoiesis that is associated with abnormal anteroposterior patterning and aberrant hox gene expression. Important to this process are the hox genes, which are believed to confer positional identities to cells along the anteroposterior axis 1, 2, 3. ![]() Organogenesis is dependent on the formation of distinct cell types within the embryo. ![]()
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